De Novo Molecular Design: A Powerful Strategy for the Discovery of New Potential Antimalarials and Antibacterials

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Launch presentation

About the speaker

Upon completion of his doctorate in synthetic organic chemistry at the University of Liverpool in 1985 Colin Fishwick joined the faculty at University of Leeds, School of Chemistry where he is currently Reader in Organic chemistry and Director of the Medicinal Chemistry and Chemical Biology (MCCB) technology support group of the Leeds Biomedicine and Health Research Centre (BHRC). He has published key findings on the application of computer-aided molecular design to the production of sub-micromolar inhibitors of bacterial and malarial enzymes and human receptors respectively. He is presently using computational and synthetic techniques to produce small-molecule inhibitors for use in the treatment of both infective- and non-infective diseases, respectively.

Abstract

Many drugs used in anticancer therapy affect indirectly or directly the cell cycle and among the most successful ones are drugs targeting mitosis or DNA replication. In this talk some of the highly attractive molecular targets in the cell cycle field including CDC-7, PLK and Aurora kinases will be presented and an update on the characteristics and the stage of the small inhibitors developed in Nerviano will be given.

Launch presentation